Heart Clinical Trials

Cedars-Sinai is ranked No. 3 in the nation and No. 1 in the western U.S. for cardiology and heart surgery, according to U.S. News & World Report. Cedars-Sinai continues to remain at the forefront of technology, innovation and discovery in heart care across the country and the world. As a patient, you'll have the opportunity to participate in clinical trials conducted by our cardiac specialists and researchers, all of whom are dedicated to advancing diagnostic and treatment options for the full range of heart conditions. 

Questions? See the Clinical Trial FAQs.



Aortic Disease

Check title--Evaluation of the GORE TAG Thoracic Branch Endoprosthesis (TBE Device)

Condition: 

Aortic Aneurysm, Thoracic
Aorta; Lesion

Check title--Evaluation of TAVR compared to Surveillance in patients with Asymptomatic severe Aortic Stenosis

Condition: 

Aortic Stenosis, Heart Diseases

Check title--Valiant Mona LSA Thoracic Stent Graft System Feasibility Study

Condition:

Aortic Aneurysm, Thoracic, Chronic Type B Dissection

Condition: 

Aortic stenosis

Key Inclusion Criteria:

  • At least 60 years old
  • Between one month and five years following transcatheter aortic valve replacement or surgical bioprosthetic aortic valve replacement

Key Exclusion Criteria: 

  • History of severe allergy to iodine contrast agents
  • Pregnant or breastfeeding
  • Active atrial fibrillation

Summary:

This study focuses on patients who have undergone a transcatheter aortic valve replacement (TAVR) or surgical bioprosthetic aortic valve replacement as part of standard of care. The narrowing of the main outlet valve of the heart (aortic stenosis) due to a build-up of calcium deposits is a common form of heart valve disease. Recently, the TAVR procedure has been developed to replace the aortic valve with a bioprosthetic tissue valve using a minimally invasive technique. The purpose of this study is to determine whether a combined positron emission tomography and computed tomography (PET-CT) heart scan using a radioactive tracer, sodium fluoride, can provide information regarding the durability of valves replaced using the TAVR procedure and conventionally placed valves. The use of sodium fluoride in this study is investigational.

Check title--Zenith®- Treatment with Acute Compicated Type B Aortic Dissection

Condition: 

Aortic Dissection

Cardiac Surgery

Condition: 

Coronary artery disease

Key Inclusion Criteria:

  • At least 18 years old
  • Scheduled to undergo an invasive coronary angiography for the assessment of coronary artery disease at the time of enrollment
  • Signed consent form and willing to allow researchers to make medical records available to GE Healthcare

Key Exclusion Criteria: 

  • Pregnant, may possibly be pregnant, or wish (including their partners) to become pregnant during the study period, or are lactating
  • Unable to undergo all imaging procedures
  • Has unstable cardiovascular condition

Summary:

This study focuses on patients who are scheduled to have an invasive coronary angiography (cardiac catheterization) as part of their standard of care. The purpose of the study is to evaluate how well an investigational imaging drug called flurpiridaz (F-18) can detect coronary artery disease. Coronary artery disease is a condition that decreases blood flow to the heart.

Pilot Study-Magnetic Resonance Imaging for Global Atherosclerosis Risk Assessment

Condition: 

Atherosclerosis

Check Title--QPI-1002 Phase 3 for Prevention of Major Adverse Kidney Events (MAKE) in Subjects at High Risk for AKI Following Cardiac Surgery

Condition: 

Cardiac Surgery