Smidt Heart Institute Takotsubo Registry

Condition: Takotsubo syndrome


Key Inclusion Criteria:

  • Diagnosis of Takotsubo syndrome
  • Submission of required medical records

Key Exclusion Criteria:

  • Less than 18 years old
  • Unable to provide documentation needed for screening purposes

Full Study Name

Smidt Heart Institute Takotsubo Registry (IRB no. 53569)


Takotsubo syndrome, sometimes called "broken heart syndrome," most often affects postmenopausal women, although it can also affect men and younger women. When a Takotsubo attack begins, it can feel much like a heart attack. Although the weakening of the heart muscle is believed to be limited in duration, cardiac problems may persist long after the initial event.

The goal of this registry is to understand how widespread Takotsubo is and to determine which individuals are at risk of experiencing additional Takotsubo events or other health problems. Registry participants will also be invited to provide a blood sample which will undergo proteomics analysis (study of proteins in the blood). Analysis of the registry's medical information and proteomics findings will enable researchers to study Takotsubo's effects on the body and determine potential treatment targets that can lead to new therapeutic strategies.

Participants' medical information, including echocardiograms (from time of hospitalization and recovery), angiograms (from hospitalization) and other hospitalization records will be entered into the registry database. Participants will also be asked to complete questionnaires that assess health status, activity levels and mobility, anxiety and depression, and physical and mental stress factors. Annual follow-up will include data collection about recurrent episodes of Takotsubo and other health issues.

Principal Investigator

C. Noel Bairey Merz, MD


Barbra Streisand Women's Heart Center Research Staff