WISE CVD - Continuation (WISE HFpEF)
Condition: Cardiovascular disease
Eligibility
Key Inclusion Criteria
For women undergoing invasive coronary angiography:
- At least 18 years old
- Symptomatic angina or anginal equivalent
For women and men with HFpEF:
- At least 18 years old
- Symptoms of heart failure
- Preserved ejection fraction, left ventricular ejection fraction ≥45% prior to study entry
Key Exclusion Criteria
For women undergoing invasive coronary angiography:
- Obstructive coronary artery disease ≥50% luminal diameter stenosis in ≥1 epicardial coronary artery
- History of coronary artery bypass grafting, coronary stent, or valve repair/replacement
For women and men with HFpEF:
- Current LVEF <45%
- History of coronary artery bypass grafting, coronary stent, or valve repair/replacement
Full Study Name
Women's Ischemia Syndrome Evaluation (WISE) - Coronary Microvascular Dysfunction (CMD) and Heart Failure With Preserved Ejection Fraction (HFpEF) (IRB no. 37321)
Summary
This study focuses on women undergoing clinically-ordered coronary angiography for suspected coronary microvascular dysfunction (small vessel disease), or men or women with heart failure with preserved ejection fraction (HFpEF). Researchers aim to better understand HFpEF (inadequate heart muscle function in the setting of preserved muscle pumping) for therapeutic strategy development and optimized noninvasive cardiac MRI for the diagnosis and management of coronary microvascular dysfunction and HFpEF.
Women undergoing clinically-ordered coronary angiography and coronary reactivity testing for suspected small vessel disease will be asked to perform rest-stress cardiac magnetic resonance imaging (CMRI) and Millar stress testing. The invasive coronary angiography and coronary reactivity testing are conducted as part of standard-of-care procedures; information from these tests will be accessed from the participant's records. Men or women with HFpEF will be asked to perform computed coronary tomography angiography to evaluate for obstructive coronary artery disease, followed by rest-stress CMRI.
Principal Investigator
C. Noel Bairey Merz, MD