Cardiac Surgery Clinical Trials

As a patient at Cedars-Sinai, you will have access to the latest clinical trials and research for cardiac surgery. Backed by a respected team of specialists and researchers, our clinical trials aim to further the advancement of diagnosing and treating your condition.

Questions? See the Clinical Trials FAQs.


Mitral valve regurgitation

Key Inclusion Criteria:

  • Adult patients ≥65 years old with moderately severe or severe primary
    degenerative mitral valve regurgitation (MR)
  • Clinical indication for mitral valve (MV) intervention and anatomic candidate for both MV transcatheter edge-to-edge and surgical repair
  • Patients across the surgical risk spectrum (low, intermediate, and high risk)


The purpose of this study is to compare the risks and benefits of two procedures used to help patients with mitral valve regurgitation (MR). The study will compare transcatheter edge-to-edge repair (TEER- a catheter procedure for repairing the mitral valve that does not require surgery to open up the heart) and mitral valve repair surgery, an open-heart surgical procedure.