COVID-19 (Coronavirus)

PREPARE Study

Condition: Fracture

Eligibility

Key Inclusion Criteria (open fracture):

  • At least 18 years old
  • Open fracture of the appendicular skeleton
  • Received or will receive definitive fracture treatment with a surgical implant(s)


Key Inclusion Criteria (closed fracture):

  • At least 18 years old
  • Closed fracture of the lower extremity or pelvis
  • Received or will receive definitive fracture treatment with a surgical implant

Key Exclusion Criteria (open fracture):

  • Fracture of the hand
  • Did not or will not receive the allocated pre-operative surgical preparation solution due to a medical contraindication
  • Received previous surgical debridement or management of fracture at a non-participating hospital or clinic

Key Exclusion Criteria (closed fracture):

  • Did not or will not receive the allocated preoperative surgical preparation solution due to a medical contraindication
  • Received previous surgical management of fracture at a non-participating hospital or clinic
  • Fracture managed outside of the participating orthopaedic service

Full Study Name

A Pragmatic Randomized Trial Evaluating Preoperative Alcohol Skin Solutions in Fractured Extremities (IRB no. 00001106)

Summary

This study focuses on individuals who have recently suffered a fracture (broken bone) that required or requires surgery. The purpose of the study is to determine which preoperative solution, iodine-povacrylex or chlorhexidine gluconate, more effectively lowers the risk of infection and complications requiring additional surgery in patients with fractures.

Prior to fracture surgery, the standard practice for orthopaedic surgeons is to wash and clean the area of the broken bone(s) immediately before surgery to lower the risk of infection. Iodine-povacrylex and chlorhexidine gluconate are commonly used at hospitals in North America and are considered to be standard of care. However, previous studies have not determined which solution is better at reducing the number of infections and complications requiring additional surgery. Prior to the participant’s surgery(ies), the surgeon used or will use one of the above solutions to wash the fracture area(s).

Principal Investigator
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