The current focus of CMIP is to develop magnetic resonance and optical agents based on small molecules, polymers, proteins and nanoparticles that can be used to interrogate molecular markers associated with various types of cancers. For example, agents currently being developed and tested in CMIP are:
- Near-infrared fluorescent dyes
- Metal chelates
- Iron oxide nanoparticles
- Polymeric nanoparticles
- Hyperpolarized metabolites and peptides
As part of this program we are investigating an emerging imaging technique, hyperpolarization, to enhance the magnetic resonance imaging signal of injectable agents in excess of 10,000 times. This technique provides a method to track and image the fate of the injectable agent minutes after administration, with imaging sequences performed in seconds. Finally, agents that possess both imaging and therapeutic agents (theranostic) are an active area of research within this program.