As a researcher, one of my key interests has centered on host-pathogen interactions. This has led me to investigate how Borrelia burgdorferi, the causative agent of Lyme Disease, remakes itself when it infects a mammalian host, and how Chlamydia pneumoniae infections can drive asthmatic responses, and also exacerbate atherosclerotic plaque development. More recently, I have become interested in the possibility that infectious agents may play a role in the development and progression of Alzheimer’s Disease. While there is evidence that infections may play a role in AD, few direct studies have been attempted, highlighting the need for new investigations.
Shimada K, Porritt RA, Markman JL, O’Rourke JG, Wakita D, Rivas MN, Ogawa C, Kozhaya L, Martins GA, Unutmaz D, Baloh RH, Crother TR, Chen S, Arditi M.
Immunity. 2018 Nov 20;49(5):873-885.e7.
Crother TR, Porritt RA, Dagvadorj J, Tumurkhuu G, Slepenkin AV, Peterson EM, Chen S, Shimada K, Arditi M.
Front Immunol. 2019 Apr 12;10:75.
Chiba N, Shimada K, Chen S, Jones HD, Alsabeh R, Slepenkin AV, Peterson E, Crother TR, Arditi M.
J Immunol. 2015 Apr 15;194(8):3840-3851.