Gonsky R, Fleshner P, Deem RL, Biener-Ramanujan E, Li D, Potdar AA, Bilsborough J, Yang S, McGovern DPB, Targan SR. Association of ribonuclease T2 gene polymorphisms with decreased expression and clinical characteristics of severity in Crohn's disease. Gastroenterology. 2017 Jul;153(1):219-232. https://www.gastrojournal.org/article/S0016-5085(17)35412-4/fulltext.
Gonsky R, Deem RL, Landers CJ, Haritunians T, Yang S, Targan SR. IFNG rs1861494 polymorphism is associated with IBD disease severity and functional changes in both IFNG methylation and protein secretion. Inflamm Bowel Dis. 2014 Oct;20(10):1794-1801. https://academic.oup.com/ibdjournal/article/20/10/1794/4578865.
Gonsky R, Deem RL, Landers CJ, Derkowski CA, Berel D, McGovern DP, Targan SR. Distinct IFNG methylation in a subset of ulcerative colitis patients based on reactivity to microbial antigens. Inflamm Bowel Dis. 2011 Jan;17(1):171-178. https://academic.oup.com/ibdjournal/article/17/1/171/4.
Gonsky R, Deem RL, Bream JH, Young HA, Targan SR. An IFNG SNP with an estrogen-like response element selectively enhances promoter expression in peripheral but not lamina propria T cells. Genes Immun. 2006 Jul;7(5):342-351. https://www.nature.com/articles/6364305.
Bream JH, Hodge DL, Gonsky R, Spolski R, Leonard WJ, Krebs S, Targan S, Morinobu A, O'Shea JJ, Young HA. A distal region in the interferon-gamma gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2. J Biol Chem. 2004 Sep 24;279(39):41249-41257. http://www.jbc.org/content/279/39/41249.long.
Contact the Gonsky Lab
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