The Wagner Laboratory is focused on the chemical and technological difficulties of enacting a fast-chemical addition of parahydrogen and the radiofrequency pulses required to convert the nuclear orientation of the two hydrogen nuclei in parahydrogen into an alignment in the third adjacent nuclei. Research in this area has already produced two promising molecules. One, hyperpolarized succinate, can be used to probe the tricarboxylic acid (TCA) cycle for research into metabolic diseases like diabetes and cancer. The other, hyperpolarized TFPP (tetrafluoroprop 1-13C-propionate), has been developed as a marker to detect fat and is currently being investigated for detecting atherosclerotic plaque. The lab’s current work is centered on generating a long-lived 15N signal that can be used as a better replacement of MR gadolinium-based contrast agents a well as molecular probes as a potential additional for molecular image done with PET. This research has demonstrated a potential to polarize amino acids that can be used track small peptides in vivo.
Gloeggler S, Kaltschnee L, Jagtap A, McCormick J, Bouchard L, Wagner S, Marcel Utz, Griesinger C.
Chemistry. 2019 Aug 22; 25(47):11031–11035.
Dutta P, Salzillo CT, Pudakalakatti S, Gammon TS, Kaipparettu AB, McAllister F, Wagner S, Frigo ED, Logothetis JC, Zacharias MN, Bhattacharya KP.
Cells. 2019, 8(4).
McCormick J, Korchak S, Mamone M, Ertas YN, Liu Z, Verlinsky L, Wagner S, Glöggler S, Bouchard LS.
Angew. Chem. Int. Ed. 2018, 57, 10692–10696.